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No specific dose adjustment advisable when tofacitinib coadministered with potent CYP2C19 inhibitors; decrease tofacitinib dose if coadministered with equally average CYP3A4 and powerful CYP2C19 inhibitors .Hepatic impairment: In sufferers with significant hepatic impairment, modafinil dose ought to be decreased by a single-50 percent of the usual